کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2553043 | 1560763 | 2007 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Role of nitric oxide/cyclic GMP/K+ channel pathways in the antinociceptive effect caused by 2,3-bis(mesitylseleno)propenol Role of nitric oxide/cyclic GMP/K+ channel pathways in the antinociceptive effect caused by 2,3-bis(mesitylseleno)propenol](/preview/png/2553043.png)
The present study examined the antinociceptive effects induced by 2,3-bis(mesitylseleno)propenol, a bis-selenide alkene derivate, given orally, in chemical models of pain in rats and mice. Selenide administered orally (p.o.) into the rats caused antinociception against the first and second phases of the formalin test, with mean ID50 values of 28.17 and 39.68 mg/kg, respectively. The antinociceptive effect caused by selenide (50 mg/kg, p.o.) on the formalin test was reversed by pretreatment with NG-l-nitro-arginine methyl ester (l-NAME, a nitric oxide (NO) synthase inhibitor), methylene blue (a non-specific NO/guanylyl cyclase inhibitor) and glibenclamide (an ATP-sensitive K+ channel inhibitor), but not by atropine (a muscarinic antagonist). Given orally selenide in mice produced an inhibition of glutamate-, histamine- and compound 48/80-induced nociception with mean ID50 values of 27.58, 36.18 and 44.53 mg/kg, respectively. Moreover, oral treatment with selenide in mice decreased licking — induced by serotonin (mean ID50 value of > 50 mg/kg). The data show that selenide exerts pronounced systemic antinociception in chemical (formalin, glutamate, histamine, compound 48/80 and serotonin-induced pain) models of nociception. Taken together, these results suggest that the antinociceptive effect of selenide on the formalin test involves the participation of nitric oxide/cyclic GMP/K+ channel pathways in rats.
Journal: Life Sciences - Volume 81, Issues 25–26, 14 December 2007, Pages 1694–1702