کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2553148 1560717 2009 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mesenchymal stem cells facilitate recovery from chemically induced liver damage and decrease liver fibrosis
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Mesenchymal stem cells facilitate recovery from chemically induced liver damage and decrease liver fibrosis
چکیده انگلیسی

AimsTo investigate the feasibility and mechanism of liver damage repair using human bone marrow mesenchymal stem cells (hBMMSCs), we investigated the potential for hBMMSCs in recovery from liver damage, including fibrotic liver repair, using the CCl4-induced model for liver damage in the rat.Main methodsRats were injected with 0.5 ml/kg CCl4 to induce liver damage and progressive liver fibrosis. hBMMSCs labeled with GFP were injected into the rats through the portal vein.Key findingsAfter one day of transplantation, GFP-labeled cells were found around the liver lobules, the hepatic blood vessels, and the edge of the liver lobes. Biochemical and histopathological analyses showed significantly increased recovery from liver damage in the transplanted group. In addition, transplanted hBMMSCs express matrix metalloproteinases (MMP), and liver fibrosis was significantly decreased. The degree of fibrosis reduction paralleled the number of hBMMSCs observed in liver sections.SignificanceOur data suggest that hBMMSCs may facilitate recovery from chronic liver damage and may decrease liver fibrosis. Therefore, hBMMSCs are a potential option for treatment of liver cirrhosis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Life Sciences - Volume 85, Issues 13–14, 23 September 2009, Pages 517–525
نویسندگان
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