کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2553170 1560749 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of chronic cold exposure on noradrenergic modulation in the preoptic area of thermoregulation in freely moving rats
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Effect of chronic cold exposure on noradrenergic modulation in the preoptic area of thermoregulation in freely moving rats
چکیده انگلیسی

For this study, we compared the thermoregulatory involvement of noradrenaline (NA) in the medial preoptic area (mPOA) of non-cold acclimated rats to that of cold-acclimated rats. We quantified the release of NA in the mPOA during 3 h cold (5 °C) exposure in room-temperature-acclimated rats (RA group, kept at 23 °C for 2 weeks) and cold-acclimated rats (CA group, kept at 5 °C for 2 weeks). We concurrently monitored the core body temperature (Tc), heart rate (HR), and tail skin temperature (Tt). Cold exposure significantly increased Tc and HR, and decreased Tt in both groups. However, the cold-induced increase of the extracellular NA levels in mPOA was observed only in the RA group: not in the CA group. To elucidate these different results in NA levels further, and to evaluate participation of the mPOA in thermoregulation in the cold, we measured Tc, HR, and Tt during perfusion of α-adrenoceptor antagonist phenoxybenzamine during cold exposure (5 °C). This pharmacological procedure induced marked hypothermia, with decreases in HR only in the RA group; no changes were observed in Tc or any thermoregulatory parameter in the CA group. These results suggest that NA in the mPOA modulates heat production in response to acute cold stress in the RA group. However, this thermoregulatory action of NA in the mPOA was attenuated in the CA group.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Life Sciences - Volume 83, Issues 1–2, 4 July 2008, Pages 79–84
نویسندگان
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