کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2553401 | 1124902 | 2005 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Carnitine depletion in rat pups from mothers given mildronate: A model of carnitine deficiency in late fetal and neonatal life
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کلمات کلیدی
CPTCATBBHjuvenile visceral steatosis - استئاتوز عصبی نوجوانانJVs - جاسوسیMildronate - مایدروناتLipid metabolism - متابولیسم لیپیدRat pups - موش صحراییCarnitine palmitoyltransferase - کارنتین پالمیتیل ترانسفرازCarnitine acetyltransferase - کارنیتین استیل ترانسفرازcarnitine deficiency - کمبود کارنیتین
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Carnitine depletion in rat pups from mothers given mildronate: A model of carnitine deficiency in late fetal and neonatal life Carnitine depletion in rat pups from mothers given mildronate: A model of carnitine deficiency in late fetal and neonatal life](/preview/png/2553401.png)
چکیده انگلیسی
The aim of this study was to evaluate the effect of mildronate administration to pregnant and lactating rats on tissue carnitine concentrations in 4- and 13-day-old rat pups. At 14 days of gestation female rats began to receive mildronate in the diet (200 mg/kg/d) and this continued for entire lactation period. Mildronate treatment determined a large reduction of carnitine levels in the milk of lactating dams. Because organ carnitine concentrations in neonatal rats are directly related to dietary supply, pups from mildronate group had significantly depleted levels of total carnitine in serum, heart, liver, muscle, brain and pancreas relative to controls, at 4 and 13 days of age. Correspondingly, an increase in triglyceride levels was observed in liver, heart and muscle of mildronate pups. This is in agreement with a reduction of basal rate of oxidation of [U-14C]-palmitate to 14CO2 and 14C-acid-soluble products observed in liver homogenates from carnitine-deficient pups. All functional and biochemical modifications were compatible with a carnitine deficiency status. In conclusion our results describe a model of carnitine depletion in pups, suitable for the investigation of carnitine deficiency in fetal-neonatal nutrition, without any concomitant mildronate-mediated metabolic alterations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Life Sciences - Volume 77, Issue 24, 28 October 2005, Pages 3078-3091
Journal: Life Sciences - Volume 77, Issue 24, 28 October 2005, Pages 3078-3091
نویسندگان
Alessandro Peschechera, Maurizio Scalibastri, Francesco Russo, Mauro Giorgio Giarrizzo, Paolo Carminati, Fabio Giannessi, Arduino Arduini, Rita Ricciolini,