کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2553828 1560760 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of morphine during Mycobacterium tuberculosis H37Rv infection in mice
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Effects of morphine during Mycobacterium tuberculosis H37Rv infection in mice
چکیده انگلیسی

The effects of opiates in various infections are well known; however, very little is known about tuberculosis infection. Therefore, in the present study, we report for the first time, the effects of morphine during murine tuberculosis. Mice were infected intravenously with Mycobacterium tuberculosis H37Rv, administered morphine (0.1–100 mg/kg subcutaneously on day 0 and day +15) and sacrificed on day +30 for CFU enumeration in lungs and spleen. Morphine exerted maximum suppression of infection at 5 mg/kg, and sometimes completes elimination of infection; naloxone, silica and aminoguanidine blocked the protective effect of morphine. In vitro, morphine lacked direct antimycobacterial activity up to 1 × 10− 4 M concentration, as assessed by radiometric BACTEC method. In macrophage model of infection, morphine showed maximal killing at 1 × 10− 7 M concentration, the activity was blocked by naloxone and aminoguanidine. These observations suggest that morphine exerts a dose-dependent effect in murine tuberculosis, the protective effect being naloxone-reversible and may involve macrophage-mediated protective mechanisms. These results may be helpful in developing new opioid-like chemical entities against tuberculosis infection.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Life Sciences - Volume 82, Issues 5–6, 30 January 2008, Pages 308–314
نویسندگان
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