کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2553853 1124930 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Acupuncture pretreatment protects heart from injury in rats with myocardial ischemia and reperfusion via inhibition of the β1-adrenoceptor signaling pathway
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Acupuncture pretreatment protects heart from injury in rats with myocardial ischemia and reperfusion via inhibition of the β1-adrenoceptor signaling pathway
چکیده انگلیسی

Our previous study showed that a cardioprotective effect was produced by pretreatment with acupuncture at bilateral Neiguan acupoints (PC6) and the effect of EA was diminished by propranolol, a nonspecific antagonist of β-adrenoceptors (β-ARs) which are the most powerful cardiac receptors, indicating an involvement of β-ARs. The present study explored further the signaling mechanism underlying the cardioprotective effect of acupuncture pretreatment in rats subjected to myocardial ischemia and reperfusion (MIR). Myocardial ischemia was achieved by ligating the left anterior descending coronary artery and reperfusion by releasing the ligation. Adult rats were divided into three groups, namely, a normal control (NC) group, a group subjected to ischemia and reperfusion (IR) only, and a group given electro-acupuncture (EA) before IR. For EA, bilateral Neiguan points (PC6) of the rats were stimulated for 30 min once a day for 3 consecutive days. The ST segment of ECG, the ratio of infarct size over risk zone, and the contents of β1-adrenoceptor (β1-AR), Gsα protein and cAMP in ischemic myocardium were compared among the three groups. IR increased the elevation of ECG ST segment, myocardial infarct size, contents of β1-AR, Gsα protein and cAMP. These effects were attenuated by EA pretreatment at bilateral Neiguan acupoints. In conclusion, the present results indicate that EA produces cardioprotective effect against IR which may be mediated via the β1-AR–Gs-protein–cAMP pathway.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Life Sciences - Volume 80, Issue 16, 27 March 2007, Pages 1484–1489
نویسندگان
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