کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2553919 | 1124935 | 2007 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Quantitative structure−activity relationship (QSAR) for neuroprotective activity of terpenoids Quantitative structure−activity relationship (QSAR) for neuroprotective activity of terpenoids](/preview/png/2553919.png)
Neuroprotective activity of thirteen terpenoids on human neuroblastoma SH-SY5Y was evaluated in vitro by using a simulated ischemia model. The protective effects on ischemic damage ranged from 3.0% to 56.5%, and trans-4,11,11-trimethyl-8-methylenebicyclo[7,2,0]undec-4-ene (trans-caryophyllene) showed the highest neuroprotective activity. A quantitative structure–activity relationship (QSAR) model was developed for eleven terpenoids with significant neuroprotective activity using TSAR software. The QSAR study produced two equations with significant predictive values (r2 and p value) and indicated that the activity was mainly governed by lipophilicity, shape index, and electrostatic property. This QSAR approach can contribute to a better understanding of structural properties of the terpenoids responsible for neuroprotection, and can be useful in predicting the neuroprotective activity of other terpenoids.
Journal: Life Sciences - Volume 80, Issue 9, 6 February 2007, Pages 835–841