کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2553945 1124937 2006 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Relaxant activity of 2-(substituted phenyl)-1H-benzimidazoles on isolated rat aortic rings
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Relaxant activity of 2-(substituted phenyl)-1H-benzimidazoles on isolated rat aortic rings
چکیده انگلیسی
The relaxant activity of 2-(o, p-substituted phenyl)-1H-benzimidazole derivatives with various 5- and 6-position substituents (-H, -CH3, -NO2, -CF3), namely 1-7, was recorded using the in vitro rat aorta ring test. Compounds 3 and 6 [2-(5-nitro-1H-benzimidazol-2-yl)phenol and 2-(4-methoxyphenyl)-5-nitro-1H-benzimidazole] were prepared using a short route, and were the most potent compounds of the series, showing IC50 value of 0.95 and 1.41 (with endothelium) and 2.01 and 3.61 μM (without endothelium), respectively. Studying further structure-activity relationships through the use of bioisosteric substitution in these benzimidazole derivatives should provide novel vasorelaxant leads and possibly against hypertensive diseases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Life Sciences - Volume 79, Issue 5, 27 June 2006, Pages 430-435
نویسندگان
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