کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2553967 1124938 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cardiovascular and pulmonary effects of NOS inhibition in endotoxemic conscious rats subjected to swimming training
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Cardiovascular and pulmonary effects of NOS inhibition in endotoxemic conscious rats subjected to swimming training
چکیده انگلیسی

Sepsis is characterized by systemic hypotension, hyporeactiveness to vasoconstrictors, impaired tissue perfusion, and multiple organ failure. During exercise training (ET), dynamic cardiovascular adjustments take place to maintain proper blood pressure and adjust blood supply to different vascular beds. The aim of this study was to investigate whether ET protects against the cardiovascular abnormalities induced by LPS, a model of experimental endotoxemia, and to evaluate the role of nitric oxide (NO) in pulmonary edema.Wistar rats were subjected to swimming training (up to 1 h/day, 5 days/week for 4 weeks) after which their femoral artery and vein were catheterized. LPS (5 mg/kg, i.v.), injected in control (C) and trained animals (ET), promoted 3 distinct phases in mean arterial pressure (MAP) and heart rate (HR). After ET the alterations in MAP were attenuated. The ET animals showed a lower pulmonary edema index (PEI) after LPS (C = 0.65 ± 0.01; ET = 0.60 ± 0.02), which was attenuated after treatment with aminoguanidine in both groups (C = 0.53 ± 0.02; ET = 0.53 ± 0.02, p < 0.05). After l-NAME, PEI was enhanced numerically in the C and was statistically higher in the ET group (C = 0.73 ± 0.05; ET = 1.30 ± 0.3, p < 0.05). 7-nitroindazole did not promote any alteration in either group.The adaptations promoted by ET seem to be beneficial, counteracting the cardiovascular abnormalities and pulmonary edema seen in septicemia induced by LPS. The results suggest that iNOS aggravates and cNOS protects against this pulmonary edema.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Life Sciences - Volume 81, Issue 16, 29 September 2007, Pages 1301–1308
نویسندگان
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