کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2554127 1124949 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Direct positive chronotropic action by angiotensin II in the isolated mouse atrium
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Direct positive chronotropic action by angiotensin II in the isolated mouse atrium
چکیده انگلیسی
We observed the direct positive chronotropic effect of angiotensin II in mouse atria and characterized its pharmacological property. C57BL/6J mice were anesthetized with pentobarbital and hearts were quickly excised. Atrial preparations including right and left atrium were isolated and suspended in the organ bath filled with Krebs-Henseleit solution gassed with 95% O2 and 5% CO2. Angiotensin II at concentrations of 10− 10 to 10− 6 M caused concentration-dependent increase in heart rate, and the maximal response was about 13% of that by isoproterenol. The effect was blocked by the selective AT1-receptor antagonist, losartan at concentrations of 10− 6 M, but not by the selective β-blocker, nadolol at concentration of 10− 5 M. Furthermore, angiotensin I also caused concentration-dependent increase in heart rate, and the effect was blocked by angiotensin converting enzyme (ACE) inhibitor, captopril at concentrations of 10− 6 M. These results suggested that angiotensin I is converted to angiotensin II via ACE system in mice atria, and regulate heart rate through AT1-receptor stimulation, not by β-adrenergic receptor.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Life Sciences - Volume 79, Issue 7, 10 July 2006, Pages 637-640
نویسندگان
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