کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2554520 | 1124973 | 2006 | 5 صفحه PDF | دانلود رایگان |

Impairment of thyroid functions brings about pathological changes in different organs of body. Findings of in vivo and in vitro studies indicate that thyroid hormones have a considerable impact on oxidative stress. Melatonin reduces oxidative damage through its free radical eliminating and direct anti-oxidant effects. The present study was undertaken to determine how a 3-week period of intraperitoneal melatonin administration affected oxidative damage caused in experimental hyperthyroidism in rat. The experimental animals were divided into 3 groups (control, hyperthyroidism, hyperthyroidism + melatonin). Malondialdehyde (MDA) and glutathione (GSH) levels were determined in different tissues.MDA levels in cerebral, liver and cardiac tissues in hyperthyroidism group were significantly higher than those in control and hyperthyroidism + melatonin supplemented groups (p < 0.001). The highest GSH levels were observed in the group that was administered melatonin in addition to having hyperthyroidism (p < 0.001).These results show that hyperthyroidism increased oxidative damage in cerebral, hepatic and cardiac tissues of rat. Melatonin supplementation may also suppress oxidative damage.
Journal: Life Sciences - Volume 79, Issue 3, 13 June 2006, Pages 311–315