کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2554520 1124973 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Melatonin prevents oxidant damage in various tissues of rats with hyperthyroidism
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Melatonin prevents oxidant damage in various tissues of rats with hyperthyroidism
چکیده انگلیسی

Impairment of thyroid functions brings about pathological changes in different organs of body. Findings of in vivo and in vitro studies indicate that thyroid hormones have a considerable impact on oxidative stress. Melatonin reduces oxidative damage through its free radical eliminating and direct anti-oxidant effects. The present study was undertaken to determine how a 3-week period of intraperitoneal melatonin administration affected oxidative damage caused in experimental hyperthyroidism in rat. The experimental animals were divided into 3 groups (control, hyperthyroidism, hyperthyroidism + melatonin). Malondialdehyde (MDA) and glutathione (GSH) levels were determined in different tissues.MDA levels in cerebral, liver and cardiac tissues in hyperthyroidism group were significantly higher than those in control and hyperthyroidism + melatonin supplemented groups (p < 0.001). The highest GSH levels were observed in the group that was administered melatonin in addition to having hyperthyroidism (p < 0.001).These results show that hyperthyroidism increased oxidative damage in cerebral, hepatic and cardiac tissues of rat. Melatonin supplementation may also suppress oxidative damage.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Life Sciences - Volume 79, Issue 3, 13 June 2006, Pages 311–315
نویسندگان
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