کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2554612 1124979 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Decreased α2-adrenergic receptor in the brain stem and pancreatic islets during pancreatic regeneration in weanling rats
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Decreased α2-adrenergic receptor in the brain stem and pancreatic islets during pancreatic regeneration in weanling rats
چکیده انگلیسی

Sympathetic stimulation inhibits insulin secretion. α2-Adrenergic receptor is known to have a regulatory role in the sympathetic function. We investigated the changes in the α2-adrenergic receptors in the brain stem and pancreatic islets using [3H]Yohimbine during pancreatic regeneration in weanling rats. Brain stem and pancreatic islets of experimental rats showed a significant decrease (p < 0.001) in norepinephrine (NE) content at 72 h after partial pancreatectomy. The epinephrine (EPI) content showed a significant decrease (p < 0.001) in pancreatic islets while it was not detected in brain stem at 72 h after partial pancreatectomy. Scatchard analysis of [3H]Yohimbine showed a significant decrease (p < 0.05) in Bmax and Kd at 72 h after partial pancreatectomy in the brain stem. In the pancreatic islets, Scatchard analysis of [3H]Yohimbine showed a significant decrease (p < 0.001) in Bmax and Kd (p < 0.05) at 72 h after partial pancreatectomy. The binding parameters reversed to near sham by 7 days after pancreatectomy both in brain stem and pancreatic islets. This shows that pancreatic insulin secretion is influenced by central nervous system inputs from the brain stem. In vitro studies with yohimbine showed that the α2-adrenergic receptors are inhibitory to islet DNA synthesis and insulin secretion. Thus our results suggest that decreased α2-adrenergic receptors during pancreatic regeneration functionally regulate insulin secretion and pancreatic β-cell proliferation in weanling rats.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Life Sciences - Volume 79, Issue 16, 13 September 2006, Pages 1507–1513
نویسندگان
, , ,