کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2554668 | 1124981 | 2006 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Passive cigarette smoking increases isoprostane formation Passive cigarette smoking increases isoprostane formation](/preview/png/2554668.png)
Passive smoking has been demonstrated to exert a variety of deleterious effects eventually resulting in vascular damage. Isoprostanes, a reliable marker of in vivo oxidation injury, have been shown to increase in active cigarette smoking. Data for passive smoking are lacking. We were examining the isoprostane 8-epi-PGF2α in 12 smokers and non-smokers exposed daily to passive cigarette smoke for 12 days. Plasma samples stored at liquid nitrogen from people having been examined earlier were used. Prevalues of 8-epi-PGF2α are higher in cigarette smokers. Exposure to passive smoking causes a significant increase in 8-epi-PGF2α in non-smokers, while in smokers there is only a trendwise increase. After repeated passive smoke exposure, 8-epi-PGF2α in non-smokers approaches the respective values of smokers. There is a significant correlation of 8-epi-PGF2α to the thromboxane (plasma, serum, conversion from exogenous precursor, 11-dehydro-TXB2) parameters (MDA, HHT- conversion) examined in these patients before. The findings document a significant temporary increase in in vivo oxidation injury due to passive smoke favouring development and/or progression of vascular disease.
Journal: Life Sciences - Volume 78, Issue 8, 18 January 2006, Pages 894–897