کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2554693 1124983 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Vasorelaxing effect of U50,488H in pulmonary artery and underlying mechanism in rats
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Vasorelaxing effect of U50,488H in pulmonary artery and underlying mechanism in rats
چکیده انگلیسی

AimTo investigate the relaxation effect and underlying mechanism of U50,488H (a selective κ-opioid receptor agonist) in pulmonary artery in the rat.MethodsIsolated pulmonary artery ring was perfused and the tension of the vessel was measured.ResultsU50,488H relaxed the pulmonary artery ring in a dose-dependent manner and the effect was abolished by nor-binaltorphimine, a selective κ-opioid receptor antagonist. The relaxation effect of U50,488H in pulmonary artery was partially endothelium-dependent and was significantly attenuated in the presence of L-NAME. The relaxation effect of U50,488H was significantly attenuated by KV channel blocker 4-AP (4-aminopyridine), but not by glibenclamide (ATP-sensitive K+ channel blocker) nor TEA (tetraethylamonium, Ca2+-activated K+ channel blocker). Further study also showed that endothelium denudation and 4-AP have an additive inhibitory effect on pulmonary artery relaxation caused by U50,488H.Conclusionκ-opioid receptor activation by U50,488H relaxes pulmonary artery via two separate pathways: one is endothelium-derived nitric oxide, the other is KV channel in pulmonary artery smooth muscle.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Life Sciences - Volume 78, Issue 21, 18 April 2006, Pages 2516–2522
نویسندگان
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