کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2554710 1124984 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Chemokine-like factor 1 is a functional ligand for CC chemokine receptor 4 (CCR4)
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Chemokine-like factor 1 is a functional ligand for CC chemokine receptor 4 (CCR4)
چکیده انگلیسی

Chemokine-like factor 1 (CKLF1) exhibits chemotactic effects on leukocytes. Its amino acid sequence shares similarity with those of TARC/CCL17 and MDC/CCL22, the cognate ligands for CCR4. The chemotactic effects of CKLF1 for CCR4-transfected cells could be desensitized by TARC/CCL17 and markedly inhibited by PTX. CKLF1 induced a calcium flux in CCR4-transfected cells and fully desensitized a subsequent response to TARC/CCL17, and TARC/CCL17 could partly desensitize the response to CKLF1. CKLF1 caused significant receptor internalization in pCCR4-EGFP transfected cells. Taken together, CKLF1 is a novel functional ligand for CCR4.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Life Sciences - Volume 78, Issue 6, 2 January 2006, Pages 614–621
نویسندگان
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