کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2554920 | 1125005 | 2006 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Could neonatal testosterone replacement prevent alterations induced by prenatal stress in male rats?
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Could neonatal testosterone replacement prevent alterations induced by prenatal stress in male rats? Could neonatal testosterone replacement prevent alterations induced by prenatal stress in male rats?](/preview/png/2554920.png)
چکیده انگلیسی
The present study was designed to examine whether testosterone replacement is able to prevent some effects of maternal restraint stress - during the period of brain sexual differentiation - on endocrine system and sexual behavior in male rat descendants. Pregnant rats were exposed to restraint stress for 1 h/day from gestational days 18 to 22. At birth, some male pups from these stressed rats received testosterone propionate. The neonatal testosterone replacement was able to prevent the reduction in anogenital distance at 22 days of age observed in pups from stressed pregnant rats as well as prevents the decrease in testosterone levels during the adulthood of these animals. Testosterone replacement in these males also presented an improvement in sexual performance. In this way, testosterone replacement probably through increasing neonatal level of this hormone was able to prevent the later alterations caused by the prenatal stress during the period of brain sexual differentiation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Life Sciences - Volume 78, Issue 24, 8 May 2006, Pages 2767-2771
Journal: Life Sciences - Volume 78, Issue 24, 8 May 2006, Pages 2767-2771
نویسندگان
Oduvaldo Câmara Marques Pereira, Maria Martha Bernardi, Daniela Cristina Ceccatto Gerardin,