کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2556417 1125220 2013 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
3,5,3′-Triiodothyronine administered to rat dams during lactation increases milk yield and triglyceride concentration and hastens pups growth
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
3,5,3′-Triiodothyronine administered to rat dams during lactation increases milk yield and triglyceride concentration and hastens pups growth
چکیده انگلیسی

SummaryIt is known that lactation induces a mild hypothyroid state in rats and other mammals while thyroid hormone administration increases milk secretion in ruminants. The aim of this study was to investigate the effects of a moderate dose of 3,5,3′triiodothyronine (T3), administered to rat dams during lactation on pups' growth and milk yield and composition. Primiparous Wistar rats with litters adjusted to 10 pups per dam received either tap water or T3 (75 μg/kg-day) in their drinking water from parturition till weaning. Food and water intake of dams and body weight of dams and pups were measured daily. In other groups of rats with similar treatments, milk yield of dams, macronutrient milk composition, and mammary arteriovenous differences for triglycerides (TG) and glucose were also determined. Dams treated with T3 ingested more food and their pups gained more weight than controls. Milk yield, milk TG concentration and glucose extraction by mammary glands were also higher in T3 treated dams. The results show that compensation of the mild hypothyroidism of the lactating rat may contribute to an increase in milk production and lipid levels, leading to an increase in growth of pups.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Life Sciences - Volume 66, Issue 21, 14 April 2000, Pages 2013-2021