کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2561635 1126946 2006 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A review on pro- and anti-angiogenic factors as targets of clinical intervention
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
A review on pro- and anti-angiogenic factors as targets of clinical intervention
چکیده انگلیسی

Angiogenesis plays an important role in physiology and pathology. It is a tightly regulated process, influenced by the microenvironment and modulated by a multitude of pro- and anti-angiogenic factors. A thorough understanding of the angiogenic process may lead to novel therapies to target ischemic vascular diseases as well as diseases characterised by excessive angiogenesis such as rheumatoid arthritis, psoriasis or tumours.This review gives an overview of the (groups of) factors involved in different steps of the angiogenic process, divided into factors affecting endothelial proliferation and migration and factors affecting blood coagulation, fibrinolysis and the degradation of basement membranes and the extra-cellular matrix, with a specific emphasis on angiopoietins and their related growth factors. The therapeutic implications of these factors are discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacological Research - Volume 53, Issue 2, February 2006, Pages 89–103
نویسندگان
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