کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2563477 1127535 2010 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sigma receptors: Potential targets for a new class of antidepressant drug
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی داروشناسی
پیش نمایش صفحه اول مقاله
Sigma receptors: Potential targets for a new class of antidepressant drug
چکیده انگلیسی

Despite the widespread and devastating impact of depression on society, our current understanding of its pathogenesis is limited. Likewise, existing treatments are inadequate, providing relief to only a subset of people suffering from depression. The search for more effective antidepressant drugs includes the investigation of new molecular targets. Among them, current data suggests that sigma receptors are involved in multiple processes effecting antidepressant-like actions in vivo and in vitro. This review summarizes accumulated evidence supporting a role for sigma receptors in antidepressant effects and provides a conceptual framework for delineating their potential roles over the course of antidepressant treatment.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacology & Therapeutics - Volume 127, Issue 3, September 2010, Pages 271–282
نویسندگان
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