کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2564774 | 1561037 | 2015 | 7 صفحه PDF | دانلود رایگان |
• Odds of autism were raised after prenatal thyroid peroxidase antibody exposure.
• The finding was observed in a large national birth cohort.
• There were no associations between maternal hypothyroidism and autism.
• This is the first biomarker-based prenatal autoimmune association with autism.
• Further prospective studies are needed to confirm this finding.
ObjectiveAutoimmune disruption may contribute to risk for autism; however, since previous studies relied upon clinical diagnoses, exposure misclassification and recall bias are limitations. Thyroid peroxidase antibody (TPO-Ab) is an autoantibody involved in autoimmune thyroiditis. We aimed to test the a priori hypothesis that positivity to maternal serum TPO-Ab (TPO-Ab +) (defined as > 156 IU/ml) during pregnancy is related to childhood autism.MethodThe study was based on a nested case-control design of the Finnish Prenatal Study of Autism (FiPS-A), a national birth cohort that includes prospectively drawn archived maternal serum specimens from virtually the entire pregnant population of Finland beginning in 1983. Cases of childhood autism (ICD-10F84.0) born from 1987 to 2005 were ascertained by performing linkages between national birth and inpatient/outpatient registries. All diagnosed cases in Finland over the birth years, and comparison subjects without ASD or severe/profound intellectual disability were matched 1:1 on date of birth, sex, birthplace, and residence in Finland. Maternal serum specimens were assayed in 967 matched case–control pairs for TPO-Ab by a chemiluminescent microparticle immunoassay blind to case/control status. Data were analyzed by conditional logistic regression for matched sets.ResultsThe prevalence of maternal TPO-Ab + was significantly increased in pregnancies giving rise to autism cases (6.15%) compared to controls (3.54%). The odds of autism were increased by nearly 80% among offspring of mothers who were TPO-Ab + during pregnancy (OR = 1.78, 95% CI = 1.16–2.75, p = 0.009), compared to mothers negative for this autoantibody. There was also a significant relationship between maternal TPO-Ab defined as a continuous variable and odds of autism (OR = 1.09, 95% CI = 1.01, 1.17, p = 0.02). Measures of maternal thyroid hormones did not differ between groups.ConclusionsThese findings provide the first biomarker-based evidence that a class of known maternal autoimmune disorders is related to autism in offspring.
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 57, 3 March 2015, Pages 86–92