کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2564984 1561054 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Neural correlates of altered response inhibition and dysfunctional connectivity at rest in obsessive–compulsive disorder
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Neural correlates of altered response inhibition and dysfunctional connectivity at rest in obsessive–compulsive disorder
چکیده انگلیسی

ObjectiveFunctional imaging studies of obsessive–compulsive disorder (OCD) have reported altered fronto-striatal activity during executive tasks. Additionally, altered connectivity of these regions during resting state was found. However, the relationship between brain activity during tasks and resting state remains poorly understood. The present study investigated neural correlates associated with abnormal response inhibition in OCD and to examine how resting state functional connectivity relates to task-related activity.MethodEighteen unmedicated adult OCD patients and 18 age- and sex-matched control subjects underwent functional magnetic resonance imaging scans during both resting state and a response inhibition task. Brain activation during response inhibition was compared between groups. Fronto-striatal regions showing altered task-related activity were used as seeds for connectivity analyses during resting state.ResultsDuring the response inhibition task, OCD patients had lower activation in areas including the cingulate cortex and basal ganglia regions. Compared with control subjects, patients with OCD showed increased functional connectivity of the caudate nucleus with the middle cingulate cortex and precentral gyrus during rest, suggesting hyperactive striatal–cortical connections.ConclusionThis study found altered function in fronto-striatal regions during response inhibition and its relation to resting state functional connectivity in OCD. Our results suggest that dysfunctional striatal–cortical connections even during rest may result in the failure of response inhibition and error monitoring observed in OCD patients.


► During the RI task, OCD patients had lower activation in the cingulate cortex.
► During the RI task, OCD patients had lower activation in the basal ganglia regions.
► Altered connectivity in OCD patients was associated with increased response time.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 40, 10 January 2013, Pages 340–346
نویسندگان
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