Adjunctive lamotrigine therapy for patients with bipolar II depression partially responsive to mood stabilizers

►Adjunctive lamotrigine leads to sustained improvement of bipolar II depression. ►Long-term use of adjunctive lamotrigine is safe and generally well-tolerated. ►The number of prior hospitalizations for depression affects response to lamotrigine. ►Suicide attempters with bipolar II depression show poor response to lamotrigine.