کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2565531 1128061 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Desipramine or glutamate antagonists synergized the antidepressant-like actions of intra-nucleus accumbens infusions of minocycline in male Wistar rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Desipramine or glutamate antagonists synergized the antidepressant-like actions of intra-nucleus accumbens infusions of minocycline in male Wistar rats
چکیده انگلیسی

Minocycline produces antidepressant-like actions in male rats tested in the forced swimming test (FST) and synergizes with several glutamate receptor antagonists. However, the limbic regions implicated in the antidepressant-like actions of minocycline are unknown. The objective of the present study was to test the potential antidepressant activity of nucleus accumbens infusions of minocycline alone or combined with antidepressant drugs or with several glutamate receptor antagonists, using the time-sampling method in the FST. The results show that intra-NAcc infusions of minocycline reduced immobility (1.0 µg, P < 0.05; 1.5 µg, P < 0.05) by increasing climbing (1.0 µg, P < 0.05; 1.5 µg, P < 0.05) in the FST. Likewise, systemic injections of desipramine (P < 0.05), fluoxetine (P < 0.05) or several glutamate receptor antagonists: EMQMCM (P < 0.05), MTEP (P < 0.05) or dizocilpine (P < 0.05) combined with intra-nucleus accumbens infusions of vehicle produced antidepressant-like actions. The subthreshold dose of intra-nucleus accumbens infusions of minocycline combined with systemic injections of subthreshold doses of desipramine (P < 0.05) or EMQMCM (P < 0.05) or MTEP (P < 0.05) or dizocilpine (P < 0.05) produced antidepressant-like actions. It is concluded that intra-NAcc infusions of minocycline alone or combined with systemic injections of desipramine or with systemic injections of several glutamate receptor antagonists produced antidepressant-like actions in the FST.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 32, Issue 7, 1 October 2008, Pages 1660–1666
نویسندگان
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