کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2565613 1128063 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The role of BDNF and HPA axis in the neurobiology of burnout syndrome
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
The role of BDNF and HPA axis in the neurobiology of burnout syndrome
چکیده انگلیسی

Chronic stress is known to affect the HPA axis. The few clinical studies which have been conducted on HPA-axis function in burnout have produced inconsistent results. The etiological relationship between sBDNF and burnout has not yet been studied. The aim of the current study was to investigate the role of BDNF and HPA axis in the neurobiology of burnout. In the current study 37 clinically diagnosed burnout participants were compared with 35 healthy controls in terms of BDNF, HPA axis, burnout symptoms, depression, anxiety and psychosomatic complaints. Basal serum cortisol, sBDNF and cortisol level after 1 mg DST was sampled. We found no significant differences in terms of HPA-axis function (for basal serum cortisol, p = 0.592; for cortisol level after 1 mg DST, p = 0.921), but we did find lowered sBDNF levels in burnout group (88.66 ± 18.15 pg/ml) as compared to healthy controls (102.18 ± 20.92 pg/ml) and the difference was statistically significant (p = 0.005). Logistic Regression Analysis revealed that emotional exhaustion (p = 0.05), depersonalization (p = 0.005) and depression (p = 0.025) were significantly associated with burnout. sBDNF levels correlated negatively with emotional exhaustion (r = −,268, p = 0.026), depersonalization (r = −,333, p = 0.005) and correlated positively with competence (r = 0.293, p = 0.015) sub-scales of burnout inventory. However, there were no significant relationships between cortisol levels and sBDNF levels (r = 0.80, p = 0.51), depression, anxiety, psychosomatic complaints and burnout inventory. Our results suggest that low BDNF might contribute to the neurobiology of burnout syndrome and it seems to be associated with burnout symptoms including altered mood and cognitive functions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 32, Issue 6, 1 August 2008, Pages 1459–1465
نویسندگان
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