کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2565749 | 1128066 | 2009 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Intrinsic neuronal plasticity in the juxtacapsular nucleus of the bed nuclei of the stria terminalis (jcBNST)
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کلمات کلیدی
ICVAPirBNSTHFSamygdalopiriform transition areaN-methyl-d-aspartic acidVTATemporal precisionPAGCeAmNMDAintracerebroventricularM-type K+ current4-APAMPAA-type K+ currentDATCRFNPYα-DTXBLAIAHP4-aminopyridine - 4-آمینوپیریدینCeA - CEAEPSP - epspiα-dendrotoxin - α-دندروتوکسینaction potential threshold - آستانه بالقوه عملStress - استرس یا فشار روانیDopamine transporter - انتقال دهنده دوپامینhigh-frequency stimulation - تحریک فرکانس بالاPeriaqueductal grey - خاکستری پرآبیDopamine - دوپامینcorticotropin releasing factor - عامل آزاد کننده کورتیکوتروپینventral tegmental area - ناحیه تگمنتوم شکمیNoradrenergic - نورآدرنژیکbed nucleus of the stria terminalis - هسته تخت ترمینال های استریcentral nucleus of the amygdala - هسته مرکزی آمیگدالbasolateral nucleus of the amygdala - هسته نزولی amygdalaReward - پاداشexcitatory post-synaptic potential - پتانسیل پس از سیناپتی هیجان انگیزGABA - گاباNeuropeptide Y - یوروپروتئین Y
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Intrinsic neuronal plasticity in the juxtacapsular nucleus of the bed nuclei of the stria terminalis (jcBNST) Intrinsic neuronal plasticity in the juxtacapsular nucleus of the bed nuclei of the stria terminalis (jcBNST)](/preview/png/2565749.png)
چکیده انگلیسی
The juxtacapsular nucleus of the anterior division of the BNST (jcBNST) receives robust glutamatergic projections from the basolateral nucleus of the amygdala (BLA), the postpiriform transition area, and the insular cortex as well as dopamine (DA) inputs from the midbrain. In turn the jcBNST sends GABAergic projections to the medial division of the central nucleus of the amygdala (CEAm) as well as other brain regions. We recently described a form of long-term potentiation of the intrinsic excitability (LTP-IE) of neurons of the juxtacapsular nucleus of BNST (jcBNST) in response to high-frequency stimulation (HFS) of the stria terminalis that was impaired during protracted withdrawal from alcohol, cocaine, and heroin and in rats chronically treated with corticotropin-releasing factor (CRF) intracerebroventricularly. Here we show that DAergic neurotransmission is required for the induction of LTP-IE of jcBNST neurons through dopamine (DA) D1 receptors. Thus, activation of the central CRF stress system and altered DAergic neurotransmission during protracted withdrawal from alcohol and drugs of abuse may contribute to the disruption of LTP-IE in the jcBNST. Impairment of this form of intrinsic neuronal plasticity in the jcBNST could result in inadequate neuronal integration and reduced inhibition of the CEA, contributing to the negative affective state that characterizes protracted abstinence in post-dependent individuals. These results provide a novel neurobiological target for vulnerability to alcohol and drug dependence.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 33, Issue 8, 13 November 2009, Pages 1347-1355
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 33, Issue 8, 13 November 2009, Pages 1347-1355
نویسندگان
Walter Francesconi, Fulvia Berton, George F. Koob, Pietro Paolo Sanna,