کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2566093 1128073 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of levetiracetam on depression and anxiety in adult epileptic patients
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Effect of levetiracetam on depression and anxiety in adult epileptic patients
چکیده انگلیسی

BackgroundInterictal depression is common in patients with epilepsy and it significantly impacts quality of life. Some studies indicate that levetiracetam (LEV) may have mood stabilizing properties.MethodsTwenty-five adults with uncontrolled partial seizures and concomitant depressive symptoms were treated with LEV. Patients were evaluated for depression and anxiety with several psychometric measures, including: Montgomery and Asberg Depression Rating Scale (MADRS), Hamilton Depression Rating Scale (HDRS), Zung Self-rating Scale for Depression (Z-SDS), Hamilton Anxiety Rating Scale (HARS), Zung Self-rating Scale for Anxiety (Z-SAS).ResultsEvaluations after 5 weeks and after 3 months of LEV treatment demonstrated significant improvement in depression and anxiety.ConclusionsThis uncontrolled study suggests that treatment with LEV may also improve depression and anxiety in patients with partial seizures. However, the sample of patients is limited and the possibility of a placebo effect cannot be excluded. These findings must be considered preliminary and should be replicated under placebo-controlled conditions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 32, Issue 2, 15 February 2008, Pages 539–543
نویسندگان
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