کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2566334 1128080 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sex differences in antidepressant-like effect of chronic repetitive transcranial magnetic stimulation in rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Sex differences in antidepressant-like effect of chronic repetitive transcranial magnetic stimulation in rats
چکیده انگلیسی

Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neurophysiological technique. Pre-clinical and clinical studies supported that rTMS might have antidepressant effects. However, whether antidepressant effect of chronic rTMS is gender-dependent is still unknown. In this study, male and female Wistar rats received 10-day rTMS (4 trains of 15 Hz; 200 stimuli/day; 1.0 T) or control condition, and then were subjected to the forced-swim test (FST). We found that female rats consistently showed higher activity levels than males in FST and revealed the significant effects of gender and rTMS as well as the interaction of gender and rTMS. The result suggested the antidepressant-like effects of chronic rTMS on behavioral components in FST are gender-dependent. The gender discrepancy related to rTMS should not be neglected in antidepressant treatment of rTMS.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 31, Issue 3, 13 April 2007, Pages 735–740
نویسندگان
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