کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2566371 1128081 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Olanzapine treatment decreases the density of muscarinic M2 receptors in the dorsal vagal complex of rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Olanzapine treatment decreases the density of muscarinic M2 receptors in the dorsal vagal complex of rats
چکیده انگلیسی

In this study, we investigated the effects of antipsychotic drugs, olanzapine and haloperidol, on the density of the muscarinic M2 receptors in the dorsal vagal complex (DVC) and hypoglossal nucleus (HN). Female Sprague Dawley rats were treated with olanzapine, haloperidol or vehicle (control) for 1 (short-term) or 12 weeks (long-term). Quantitative autoradiography was used to investigate the M2 receptor density in the DVC and HN using a muscarinic antagonist [3H] AF-DX384. Olanzapine, but not haloperidol, treatment induced a significant decrease in the binding density of M2 receptors in the DVC compared to control groups. Although the HN showed a higher density of [3H] AF-DX384 binding than the DVC, treatment with both olanzapine and haloperidol did not induce any significant changes in [3H] AF-DX384 binding in the HN. These results suggest that olanzapine-induced body weight gain may be associated with functional changes in the muscarinic neurotransmission in the DVC.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 31, Issue 4, 9 May 2007, Pages 915–920
نویسندگان
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