کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2566526 | 1128085 | 2007 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Association between obsessive–compulsive disorder and a variable number of tandem repeats polymorphism in intron 2 of the serotonin transporter gene Association between obsessive–compulsive disorder and a variable number of tandem repeats polymorphism in intron 2 of the serotonin transporter gene](/preview/png/2566526.png)
BackgroundPharmacological studies indicate a dysregulation of the serotonergic system in obsessive–compulsive disorder (OCD). A variable number tandem repeats (VNTR) polymorphism with three alleles (Stin2.9, Stin2.10, Stin2.12) has been described in intron 2 of the serotonin transporter (5-HTT) gene. This polymorphism has been associated with unipolar depression, bipolar disorder, schizophrenia, and anxiety disorders including OCD.MethodsThe association between OCD and the polymorphism is examined in 97 OCD patients, 578 psychiatric controls and 406 healthy controls, all Spanish Caucasians.ResultsGenotype frequencies for the polymorphism were significantly different in OCD patients, psychiatric patients and controls. There was a significant excess of 12/12 and 12/10 genotypes in OCD patients compared to psychiatric patients and controls.ConclusionsOur results indicate a possible association between the Stin2.12 allele of the VNTR polymorphism and OCD.
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 31, Issue 2, 30 March 2007, Pages 416–420