کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2566581 | 1128086 | 2008 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Family-based association studies of CAPON and schizophrenia in the Chinese Han population
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Family-based association studies of CAPON and schizophrenia in the Chinese Han population Family-based association studies of CAPON and schizophrenia in the Chinese Han population](/preview/png/2566581.png)
چکیده انگلیسی
Although there is evidence pointing to CAPON as a susceptible gene for schizophrenia, the results of independent association studies have so far been inconsistent. A recent case-control study by Zheng et al. supported CAPON as a susceptible site for the disease in the Chinese Han population. In their study both the single polymorphism (rs348624) and individual haplotypes showed significant association with schizophrenia. Our study further investigates this relationship this time using a family-based association. We selected 5 SNPs including rs348624 and performed a Transmission Disequilibrium Test (TDT) in 319 Chinese Han trios. Our results identified no single marker nor haplotype associated with schizophrenia, which did not suggest that CAPON was a susceptible site in the Chinese Han population, or it appeared unlikely that the CAPON played a major role in the aetiology of schizophrenia. Since there is consistent evidence pointing to 1q21-22 as a positional candidate region for schizophrenia, we suggest that further research should focus on other genes located in this region.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 32, Issue 5, 1 July 2008, Pages 1210-1213
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 32, Issue 5, 1 July 2008, Pages 1210-1213
نویسندگان
C. Fang, W. Tang, R.Q. Tang, L. Wang, G.Q. Zhou, K. Huang, X.W. Li, G.Y. Feng, M. He, L.Z. Du, S.M. Zhu, Y.L. Xing, H. Sang, L. He, Y.Y. Shi,