کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2566977 | 1561090 | 2015 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Serum levels of tumor necrosis factor-related apoptosis-inducing ligand correlate with the severity of pulmonary hypertension
ترجمه فارسی عنوان
سطوح سرمی لیگاند ناشی از آپوپتوز مرتبط با عامل نکروز تومور در ارتباط با شدت فشار خون ریوی
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کلمات کلیدی
CTEPHPAHRVSPCTDRVHhs-CRPIPAH6MWDCHDLHDLVEFConnective tissue disease - بیماری بافت همبندcoronary artery disease - بیماری عروق کرونرCongenital heart disease - بیماری قلبی مادرزادیPulmonary artery smooth muscle cell - سلول عضله صحی عروق ریویCAD - طراحی به کمک رایانه یا کَدPulmonary arterial hypertension - فشار خون شریانی ریویChronic thromboembolic pulmonary hypertension - فشارخون ریوی ترومبوآمبولیک مزمنTRAIL - قطارtumor necrosis factor-related apoptosis-inducing ligand - لیگاند ناشی از آپوپتوز وابسته به عامل بیماری تومورMouse model - مدل موشRight ventricular hypertrophy - هیپرتروفی بطنی راستPulmonary hypertension - پرفشاری خون ریویIdiopathic pulmonary arterial hypertension - پرفشاری خون شریانی ریوی ایدیوپاتیکhigh-sensitivity C-reactive protein - پروتئین واکنش پذیر با حساسیت بالا Cleft ventricular ejection fraction - کسر خروجی بطن چپ
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
پزشکی ریوی و تنفسی
چکیده انگلیسی
Pulmonary hypertension (PH) is a rapidly progressive disease that eventually leads to right heart failure and death. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and its receptors (TRAIL-Rs) play an important role in the survival, migration, and proliferation of vascular smooth muscle cells. However, the association between serum TRAIL levels and PH is unknown. In this study, we assayed the serum soluble TRAIL (sTRAIL) levels in 78 patients with PH and 80 controls. The sTRAIL concentrations were elevated in the PH patients compared with the controls (138.76 ± 6.60 pg/mL vs. 80.14 ± 3.38 pg/mL, p < 0.0001). The presence of sTRAIL levels of >103 pg/mL could discriminate PH patients from healthy individuals, with a sensitivity of 75.6% and specificity of 81.2%. Moreover, elevated sTRAIL concentrations were associated with eventual pathological complications; this is consistent with the finding that sTRAIL levels decreased in patients who responded to treatment. In a hypoxia-induced PH mouse model, sTRAIL levels were significantly higher compared with those in normoxia mice, and clearly decreased when the mice were treated with treprostinil. The sTRAIL levels were positively correlated with right ventricular systolic pressure and the index of right ventricular hypertrophy. In conclusion, serum sTRAIL could be a biomarker for diagnosis and effective therapy for PH patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pulmonary Pharmacology & Therapeutics - Volume 33, August 2015, Pages 39-46
Journal: Pulmonary Pharmacology & Therapeutics - Volume 33, August 2015, Pages 39-46
نویسندگان
Huan Liu, Erli Yang, Xiaolan Lu, Caojian Zuo, Yuhu He, Daile Jia, Qian Zhu, Ying Yu, Ankang Lv,