کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2567705 1128343 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Lung function and symptom improvement with fluticasone propionate/salmeterol and ipratropium bromide/albuterol in COPD: Response by beta-agonist reversibility
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی ریوی و تنفسی
پیش نمایش صفحه اول مقاله
Lung function and symptom improvement with fluticasone propionate/salmeterol and ipratropium bromide/albuterol in COPD: Response by beta-agonist reversibility
چکیده انگلیسی

This retrospective analysis of data from two multi-center, randomized, double-blind, parallel group studies compared the efficacy of fluticasone propionate/salmeterol (FSC) 250/50 mcg twice daily with ipratropium bromide/albuterol (IB/ALB) 36/206 mcg four times daily in albuterol-reversible (n=320 [44%]) and non-reversible (n=399 [56%]) patients with COPD. In reversible and non-reversible patients, both treatments significantly increased FEV1AUC0–6h from baseline and the magnitude of improvement was larger in reversible patients. FSC increased FEV1AUC0–6h by 1.46±0.08 and 1.98±0.13 l-h at Day 1 and Week 8, respectively, in reversible patients, compared with 0.71±0.06 and 0.94±0.10 l-h in non-reversible patients (p<0.001). With IB/ALB, increases were 1.46±0.08 and 1.19±0.11 l-h at Day 1 in reversible patients and Week 8, respectively, and 0.89±0.06 and 0.74±0.09 l-h (p⩽0.041) in non-reversible patients. After 8 weeks, in both the reversible and non-reversible populations, the FEV1 AUC0–6h significantly increased with FSC treatment (p⩽0.002) and significantly decreased with IB/ALB (p⩽0.010). In both reversibility groups, improvement in Transition Dyspnea Index (TDI) scores, overall daytime diary symptom scores and nocturnal symptom measures were significantly greater with FSC treatment compared with IB/ALB (p⩽0.044). Reversibility status was not predictive of the magnitude of reduction in symptom scores. We conclude that both reversible and non-reversible patients receive greater clinical benefit with FSC compared with IB/ALB and acute bronchodilator reversibility is not useful for differentiating patients based on symptomatic responses to FSC compared with IB/ALB.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pulmonary Pharmacology & Therapeutics - Volume 21, Issue 4, August 2008, Pages 682–688
نویسندگان
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