کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2567726 1128345 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of prolonged use of azithromycin in patients with cystic fibrosis: A meta-analysis
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی ریوی و تنفسی
پیش نمایش صفحه اول مقاله
Effects of prolonged use of azithromycin in patients with cystic fibrosis: A meta-analysis
چکیده انگلیسی

Azithromycin has been studied as potential therapeutic anti-inflammatory agent for cystic fibrosis (CF) patients. Azithromycin (AZM) has been used as an immunomodulating agent, based on few small studies. Considering the cost and potential side effects of long-term azithromycin therapy, it is important to identify the group of patients that would benefit the most. Weighted mean difference was used for pulmonary function tests, and risk ratios for all other variables. The random-effects model was applied for all reports. Combining four studies (N = 368), azithromycin showed increase in FEV1 (3.53%, 95% CI 0.00, 7.07, p = 0.05; I2 = 38%) and FVC (4.24%, 95% CI 2.02, 6.45, p = 0.0002; I2 = 0%). When trials were analyzed by baseline Pseudomonas sputum colonization, the heterogeneity decreased (I2 = 0%), FEV1 significantly increased to 4.66% (95% CI 1.18, 8.15, p = 0.009), and FVC increased to 4.64% (95% CI 2.11, 7.17, p = 0.0003). The GI side effects were 72% higher with azithromycin use (RR 1.72, 95% CI 1.33, 2.21, p = 0.00003), the main side effects being nausea (RR 2.04, 95% CI 1.19, 3.45, p = 0.009), and diarrhea (RR 2.12, 95% CI 1.10, 4.08, p = 0.02). Azithromycin improves lung function of CF patients, especially in the subgroup colonized with Pseudomonas. However, nausea and diarrhea are significantly more frequent with azythromycin.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pulmonary Pharmacology & Therapeutics - Volume 22, Issue 6, December 2009, Pages 467–472
نویسندگان
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