کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2567757 1128347 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Sildenafil improves hemodynamic parameters in COPD—an investigation of six patients
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی ریوی و تنفسی
پیش نمایش صفحه اول مقاله
Sildenafil improves hemodynamic parameters in COPD—an investigation of six patients
چکیده انگلیسی

Pulmonary hypertension (PH) is an important predictor of mortality in chronic obstructive pulmonary disease (COPD). The phosphodiesterase 5 inhibitor sildenafil has been demonstrated to reduce pulmonary arterial pressure (PAP) in different diseases. We wanted to investigate the effect of sildenafil on hemodynamic parameters and the 6-min walk test (6 MWT) in six patients with severe COPD and echocardiographically estimated PH. A 6 MWT was performed and hemodynamic parameters were measured by right heart catheterization before and 1 and 12 h after injection of 50 mg sildenafil intravenously. A 3-months period of peroral sildenafil therapy 50 mg twice daily followed and finally hemodynamic parameters and a 6 MWT were repeated. Intravenously applied sildenafil could be demonstrated to reduce PAP and pulmonary vasculature resistance (PVR) significantly. And after 3 months of oral sildenafil, the mean PAP has decreased from 30.2±5.5 mmHg (range: 24–39 mmHg) to 24.6±4.2 mmHg (range: 20–30 mmHg) (p=0.01p=0.01). The PVR has decreased from 401±108 dyn s cm−5 (range: 266–558 dyn s cm−5) to 264±52 dyn s cm−5 (range: 204–333 dyn s cm−5) (p<0.05p<0.05). Physical conditions improved: the 6-min walk distance increased from 351±49 to 433±52 m. In conclusion, in six patients suffering from severe COPD we could demonstrate significantly improved hemodynamic parameters after 50 mg sildenafil intravenous application. And after 3 months of oral sildenafil, walking distance in the 6 MWT increased significantly as well as hemodynamic parameters in the five patients who had accepted a second right heart catheterization.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pulmonary Pharmacology & Therapeutics - Volume 19, Issue 6, December 2006, Pages 386–390
نویسندگان
, , , ,