کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2574637 1129704 2007 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Differential effects of peroxynitrite on the function of arginine vasopressin V1a receptors and alpha1-adrenoceptors in vivo
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Differential effects of peroxynitrite on the function of arginine vasopressin V1a receptors and alpha1-adrenoceptors in vivo
چکیده انگلیسی

ObjectiveThe aim of this study was to provide evidence that peroxynitrite may differentially affect the function of arginine vasopressin (AVP) V1a receptors and α1-adrenoceptors in vascular smooth muscle of the ratMethodsThe vasoconstrictor responses elicited by AVP, or the α1-adrenoceptor agonist, phenylephrine, were determined in anesthetized rats before and after injections of (i) peroxynitrite, the thiol chelator, para-hydroxymercurobenzoic acid (PHMBA), or the electron acceptor, nitroblue tetrazolium (NBT). The ability of the reducing agent, glutathione, to reverse the loss of response to phenylephrine and AVP in peroxynitrite-treated rats was also examined.ResultsThe AVP-induced responses were suppressed 10–20 min but not 60–70 min after the administration of peroxynitrite. Glutathione reversed the above loss of response to AVP at 10–20 min. The responses elicited by phenylephrine were suppressed 10–20 min and 60–70 min after administration of peroxynitrite. Glutathione did not reverse the above losses of response to phenylephrine. In addition, the vasoconstrictor actions of AVP and phenylephrine were markedly suppressed after administration of PHMBA or nitroblue tetrazolium.ConclusionsThe above findings provide evidence that exogenously administered peroxynitrite may differentially affect the function of AVP V1a receptors and α1-adrenoceptors in vascular smooth muscle of the rat. The possibility that peroxynitrite impairs AVP V1a receptor function by transient oxidation events whereas peroxynitrite impairs α1-adrenoceptor function by transient oxidation and permanent nitration events will be discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Vascular Pharmacology - Volume 46, Issue 1, January 2007, Pages 24–34
نویسندگان
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