کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2583361 1130687 2011 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Toxicological evaluation of Pterocaulon polystachyum extract: A medicinal plant with antifungal activity
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Toxicological evaluation of Pterocaulon polystachyum extract: A medicinal plant with antifungal activity
چکیده انگلیسی

Pterocaulon polystachyum DC is a native species to southern Brazil, Paraguay, Uruguay and northeastern Argentina. It is utilized to treat animal problems popularly diagnosed as “mycoses”. The antifungal and amebicidal activity of its hexane extract has been previously reported, although there are no studies confirming the safety of this plant for therapeutic purposes to date. Hence, this study investigates the toxic effects of a hexane extract of Pterocaulon polystachyum administered as acute and subacute oral treatments. After acute treatment the extract caused alterations in biochemical parameters, morphological alterations in tissues and was genotoxic, according to the comet assay; neither mortality nor visible signs of lethality were seen in mice. Similarly subacute treatment caused important differences in biochemical parameters and tissues, between control and treated groups. The results also revealed genotoxicity in kidney tissue, though no mutagenicity was detected by the micronucleus test. No animal died during the treatment period.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Toxicology and Pharmacology - Volume 31, Issue 1, January 2011, Pages 242–249
نویسندگان
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