Diiodomethyl-p-tolylsulfone: Evaluation of the mode of action for reproductive toxicity

► Mode of action for reproductive toxicity of DIMPTS is hypothyroidism from excess iodine levels. ► Testicular development in the neonate is the tissue most sensitive to iodine toxicity. ► Neonates born to mothers with excessive iodine intake exhibit signs of transient hypothyroidism. ► Exposures to iodinated substances are less than 1% of the iodine RDI for normal development. ► Exposures to DIMPTS do not represent any risk to health at any life-stage.