کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2592752 1132044 2007 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
What do we (need to) know about the kinetic properties of nanoparticles in the body?
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
What do we (need to) know about the kinetic properties of nanoparticles in the body?
چکیده انگلیسی

Nowadays the development and applications of nanotechnology are of major importance in both industrial and consumer areas. However, the knowledge on human exposure and possible toxicity of nanotechnology products is limited. To understand the mechanism of toxicity, thorough knowledge of the toxicokinetic properties of nanoparticles is warranted. There is a need for information on the absorption, distribution, metabolism and excretion (ADME) of nanoparticles and validated detection methods of these man-made nanoparticles. Determination of the ADME properties of nanoparticles requires specialised detection methods in different biological matrices (e.g. blood and organs). In this paper, the current knowledge on the kinetic properties of nanoparticles is reviewed. Moreover, knowledge gaps from a kinetic point of view (detection, dose, ADME processes) are identified.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 49, Issue 3, December 2007, Pages 217–229
نویسندگان
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