کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2593613 | 1562180 | 2013 | 8 صفحه PDF | دانلود رایگان |
• Infants born to epileptic women have an increased risk of major congenital malformations.
• Prenatal exposure to antiepileptic drugs is the main cause of birth defects.
• The teratogenic role of maternal epilepsy cannot be excluded.
Infants born to epileptic women treated with antiepileptic drugs (AEDs) have an increased risk of major congenital malformations (MCMs).In order to determine the role of maternal epilepsy we conducted a prospective cohort study on three cohorts of pregnant women: (i) 385 epileptic women treated with AEDs, (ii) 310 non-epileptic women treated with AEDs, (iii) 867 healthy women not exposed to AEDs (control group). The rate of MCMs in the epileptic group (7.7%) was not statistically higher than in the non-epileptic one (3.9%) (p = 0.068). The rate in the first group was higher compared to the control group (p = 0.001), while the rate in the second one was not (p = 0.534).Our data confirm that AEDs therapy is the main cause of the increased risk of malformations in the offspring of epileptic women; however a teratogenic role of the maternal epilepsy itself cannot be excluded.
Journal: Reproductive Toxicology - Volume 39, August 2013, Pages 50–57