کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2593814 1132250 2012 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Preliminary findings of the developmental effects of in utero exposure to topiramate
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Preliminary findings of the developmental effects of in utero exposure to topiramate
چکیده انگلیسی
There are relatively few studies that have looked at the longer-term developmental effects of intra-uterine topiramate exposure. The purpose of this report is to describe preliminary findings of the developmental outcomes of a group of nine children of preschool age (3-6 years, 11 months), exposed in utero to topiramate (TX) monotherapy, as compared to a control group of 18 children. The groups were compared on developmental measures of visual, fine and gross motor function as well as measures of behavior and cognitive functions. Results showed that the TX group performed significantly worse than the control group for almost all measures, with the most clearly delineated differences in the area of cognitive functioning. While the study group is small, and only preliminary conclusions may be inferred, it appears that TX exposure may have subtle effects on the development of children in a range of areas including motor function, cognition, and behavior.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive Toxicology - Volume 34, Issue 3, November 2012, Pages 308-311
نویسندگان
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