کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2593833 1132250 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The effect of prenatal and postnatal exposure to polychlorinated biphenyls and child neurodevelopment at age twenty four months
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
The effect of prenatal and postnatal exposure to polychlorinated biphenyls and child neurodevelopment at age twenty four months
چکیده انگلیسی

We examined the association between prenatal and postnatal exposure to PCBs and development at age 24 months as measured by the Bayley Scales of Infant Development II. 44 (85%) of 52 children had information available. When prenatal and postnatal exposure were modeled together, we found no association between total PCB exposure and the mental development index (MDI) or the physical development index (PDI). In examining PCB 153, we found no association between PCB 153 and MDI, while higher levels of postnatal exposure was associated with a decrease in PDI after adjustment [β for highest tertile = −24.9; 95% CI (−44.3, −5.5)]. Higher levels of prenatal PCB 153 exposure were associated with a statistically significant increased odds of screening positive for a motor delay. In sum, when prenatal and postnatal exposures were considered together, breast milk exposure to PCB 153 appears to be associated with decrements in motor development; however, we cannot rule out that the finding was due to chance.


► We modeled the association between pre and postnatal exposure to PCBs and child neurodevelopment.
► No association was seen between pre and postnatal total PCBs and neurodevelopment.
► When prenatal and postnatal exposure were modeled together, postnatal PCB 153 level decreased PDI; however, the finding might be due to chance.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive Toxicology - Volume 34, Issue 3, November 2012, Pages 451–456
نویسندگان
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