Paternal treatment with cisplatin impairs reproduction of adult male offspring in rats

This study evaluated the acute and persistent effects of paternal cisplatin-treatment on progeny. Wistar male rats (45 days old) were assigned into 2 groups. Control and cisplatin (CP: 1 mg/kg-d, 5 days/week, for 3 weeks, ip.). Male rats at 66 (end of treatment, acute effects evaluation) and 140 days old (after recovery period, persistent effects evaluation) were mated with females. Fetal and post-natal developments of the offspring sired by treated-male mated in both ages were evaluated, including fertility of adult male offspring. No adverse effects in fetal development or puberty onset were seen in CP offspring. However, testicular descent was delayed and postnatal growth was impaired in these animals (acute effect). Moreover, seminal vesicle weight and epididymal sperm count from adult progeny were affected (acute effects) by paternal CP-exposure. The only persistent effect found was alterations in the spermatogenesis. We conclude that paternal CP-administration during peri-puberty affects reproductive endpoints of the progeny.

► Acute and persistent effects of the paternal cisplatin-treatment on progeny.
► No adverse effects in fetal development or puberty onset were found.
► Cisplatin affected testicular descent, epididymal sperm count and growth.
► The only persistent effect found was alterations in the spermatogenesis.
► Paternal cisplatin-exposure during peri-puberty affects reproduction of the progeny.