کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2594458 1132270 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The safety of calcium channel blockers during pregnancy: A prospective, multicenter, observational study
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
The safety of calcium channel blockers during pregnancy: A prospective, multicenter, observational study
چکیده انگلیسی

ObjectiveTo assess the safety of calcium channel blockers during the first trimester of pregnancy.Study designA multicenter (n = 11), prospective observational study of the European Network of Teratology Information Services (ENTIS). The rate of major birth defects was compared between a cohort of pregnant women exposed to calcium channel blockers during the first trimester (n = 299) and a control group not exposed to potential teratogens (n = 806).ResultsMajor birth defects were not more common in the study group than in the control group. Birth weight was significantly lower in exposed term newborns. There were more preterm infants in the study group than in the control group (23.8% vs. 6.5%). These adverse effects are more likely due to the underlying disease than to the medication.ConclusionThis study suggests that calcium channel blockers during the first trimester of pregnancy do not represent a major teratogenic risk.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive Toxicology - Volume 26, Issue 1, September 2008, Pages 24–30
نویسندگان
, , , , , , , , , , , ,