کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2594871 1132284 2006 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Postulated pathogenic pathway in triazole fungicide induced dysmorphogenic effects
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Postulated pathogenic pathway in triazole fungicide induced dysmorphogenic effects
چکیده انگلیسی

Triazole fungicides are used in medicine as well as in agricultural treatment of mycoses. The pharmacological mechanism is related to the inhibition of CYP enzymes involved in the formation of the fungal walls. A similar inhibition of human CYP enzymes has been suggested as the cause of triazole side effects in humans. An importent role of some CYP isoforms (CYP26 isoforms) expressed during mammalian development is the catabolism of retinoic acid, a known morphogen in vertebrates and invertebrates. The adverse effects on morphogenesis, observed after exposure of mammalian, anfibian and ascidiacea, are compared to the reported effects of triazole in humans. The possible pathogenic pathway in triazole-related teratogenesis is discussed on the basis of different experimental approaches.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive Toxicology - Volume 22, Issue 2, August 2006, Pages 186–195
نویسندگان
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