کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2594874 1132284 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Inherited and acquired thrombophilia: Pregnancy outcome and treatment
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Inherited and acquired thrombophilia: Pregnancy outcome and treatment
چکیده انگلیسی

Maternal thrombophilias increases the risk of an adverse pregnancy outcome.An extensive literature review highlights the role of inherited and acquired thombophilic disorders in spontaneous abortion, both early and late, recurrent or isolate, in intrauterine growth retardation, in placenta abruption, in pre-eclampsia and in venous thromboembolism. We have particularly focused attention on the following factors: antithrombin III (ATIII), proteins C (PC) and S (PS) deficiencies, genetic mutations particularly factor V Leiden (FVL), prothrombin gene G20210A (PTM) and the thermolabile variant of the methylene tetrahydrofolate reductase C677T (MTHFR) gene, lupus anticoagulant (LAC) and anticardiolipin antibodies, VIIIc factor, hyperhomocysteinemia and acquired activated protein C resistance.Appropriate treatment can improve pregnancy outcome without teratogenic effects.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive Toxicology - Volume 22, Issue 2, August 2006, Pages 227–233
نویسندگان
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