کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2595105 1132291 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The adverse effect of dichlorodiphenyltrichloroethane (DDT) and its metabolite (DDE) on the secretion of prostaglandins and oxytocin in bovine cultured ovarian and endometrial cells
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
The adverse effect of dichlorodiphenyltrichloroethane (DDT) and its metabolite (DDE) on the secretion of prostaglandins and oxytocin in bovine cultured ovarian and endometrial cells
چکیده انگلیسی

The influence of chlorinated hydrocarbon insecticide—dichlorodiphenyltrichloroethane (DDT) and its metabolite (DDE) on the uterine prostaglandin (PGF2α and PGE2) and ovarian oxytocin (OT) secretion was investigated. Endometrial, granulosa and luteal cells from cows and heifers on 8–12 days of estrous cycle were treated (24–72 h) with DDT, mixture or individual isomer (p,p′-, o,p′-) of DDE (0.1, 1 or 10 ng/ml). The viability of cells and the concentrations of hormones in medium were determinted. Neither DDT nor DDE affected (P > 0.05) the viability of cells, while they stimulated (P < 0.05) PGF2α and reduced (P < 0.001) PGE2 secretion from endometrial cells. Hence the ratio of PGF2α to PGE2 was markedly changed. Used pollutants also increased (P < 0.05) OT secretion from ovarian cells. It is concluded that DDT and its metabolite impair PGF2α, PGE2 and OT secretion from uterus and ovary, respectively, and this way they can affect the course of estrous cycle in cattle.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive Toxicology - Volume 27, Issue 1, January 2009, Pages 72–78
نویسندگان
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