کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2595142 1132294 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Circulating estradiol in men is inversely related to urinary metabolites of nonpersistent insecticides
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Circulating estradiol in men is inversely related to urinary metabolites of nonpersistent insecticides
چکیده انگلیسی

BackgroundEstradiol plays an important role in male reproductive health as a germ cell survival factor. Chlorpyrifos and carbaryl, nonpersistent insecticides to which the general population are commonly exposed, were recently shown to inhibit estradiol metabolism in vitro which could lead to altered hormone balance.MethodsSubjects (N = 322) were the male partners in couples presenting to a Massachusetts infertility clinic from years 2000–2003. 3,5,6-Trichloro-2-pyridinol (TCPY), the major urinary metabolite of chlorpyrifos and chlorpyrifos-methyl, and 1- and 2-naphthol (1N and 2N), urinary metabolites of carbaryl and naphthalene, were measured in a spot urine sample from each subject. Estradiol, sex hormone binding globulin (SHBG), and prolactin were measured in serum collected from subjects during the same clinic visit.ResultsUsing multiple linear regression, an interquartile range (IQR) increase in TCPY was associated with a 1.36 pg/mL decline (95% confidence interval = −2.91 to −0.22) in estradiol concentration. When estradiol and TCPY were divided into quintiles, there was a dose-dependent increase in the odds of being in the lowest estradiol quintile with increasing TCPY quintiles.ConclusionOn a population level, these reductions in estradiol levels are of potential public health importance because of widespread exposure to TCPY and its parent insecticides.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive Toxicology - Volume 25, Issue 2, February 2008, Pages 184–191
نویسندگان
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