کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2595146 1132294 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Blood manganese concentrations and intrauterine growth restriction
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Blood manganese concentrations and intrauterine growth restriction
چکیده انگلیسی

To assess the relationship between blood concentrations of manganese (Mn) and intrauterine growth restriction (IUGR), Mn levels in the umbilical cord blood (UCB) and the mother whole blood (MWB) samples were measured in apparently healthy mothers and their newborns. Measurement was conducted by an inductively coupled plasma mass spectrometry. Manganese concentrations in MWB were significantly lower (p < 0.01) in IUGR cases than in appropriate for gestational age (AGA) cases (mean ± S.D.; 16.7 ± 4.8 and 19.1 ± 5.9 μg/l, respectively). Conversely, UCB concentrations of Mn were significantly higher (p < 0.05) in IUGR newborns than AGA newborns (44.7 ± 19.1 and 38.2 ± 13.1 μg/l, respectively). Logistic regression analysis demonstrated significant relationships of the mother whole blood and the umbilical cord blood concentrations of Mn in IUGR cases (OR = 0.868, 1.044, respectively). The study suggests that manganese concentrations in MWB and UCB might induce different effects on birth weight in healthy mothers. Because intrauterine growth restriction is a multi-factorial problem, further epidemiological and clinical studies on larger numbers of subjects are needed to confirm the findings in the present study.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive Toxicology - Volume 25, Issue 2, February 2008, Pages 219–223
نویسندگان
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