Bisphenol-A and chlorinated derivatives in adipose tissue of women

Bisphenol-A (BPA) and chlorinated derivatives (ClxBPA) were investigated in adipose tissue of women in Southeast Spain. BPA was above limit of detection (LOD) in 11 out of 20 samples (55%). Among ClxBPA, Cl2BPA was the most frequent (80%) and abundant, constituting 94.6% of total chlorinated BPA in adipose tissue. Mean ± S.D. of BPA, monochloro-BPA (ClBPA), dichloro-BPA (Cl2BPA), and trichloro-BPA (Cl3BPA) were 5.83 ± 3.48, 3.05 ± 0.28, 9.21 ± 9.26, and 0.74 ± 0.15 ng/g of adipose tissue, respectively. No tetrachloro-BPA (Cl4BPA) was found above LOD. There are no published data on BPA in human adipose tissue or on ClxBPA in adipose tissue or blood, limiting comparisons. BPA levels were similar (w/w) to findings in blood (w/v) in other populations and below levels reported in placenta tissue (w/w). Because of the estrogen mimicking effects of BPA and its ClxBPA, further research is needed to explore their combined effects on human health and trends in human exposure.