کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2595287 1132307 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Early changes in sperm motility, acrosome reaction, and gene expression of reproductive organs in rats treated with sulfasalazine
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Early changes in sperm motility, acrosome reaction, and gene expression of reproductive organs in rats treated with sulfasalazine
چکیده انگلیسی

Previously, we reported that decreased epididymal expression of CD59 and decay accelerating factor (DAF) genes may affect sperm motility and the acrosome reaction in rats treated long-term (28 days) with sulfasalazine. To investigate the early effects of sulfasalazine on the male reproductive tract, we presently examined sperm motility, the acrosome reaction, and gene expression in the testes and epididymides of rats treated with sulfasalazine for 1, 7 or 14 days. Reduced sperm motility and acrosome reactions were noted on day 7, however, there were no remarkable changes in testicular gene expression. On the other hand, attenuated epididymal gene expression of CD59 and DAF was observed as early as day 1. As CD59 and DAF are secreted from the epididymis and play a role in sperm maturation, we hypothesize that sulfasalazine affects sperm maturation as an early effect and that CD59 and DAF genes are related to the negative effect.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive Toxicology - Volume 23, Issue 2, February 2007, Pages 153–157
نویسندگان
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